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MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2
Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and pro-survival factors, the most important of which is the NAD(+) biosynthetic enzyme NMNAT2 that inhibits activation of the SARM1 pathway. Here we inves...
Autores principales: | Walker, Lauren J, Summers, Daniel W, Sasaki, Yo, Brace, EJ, Milbrandt, Jeffrey, DiAntonio, Aaron |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241118/ https://www.ncbi.nlm.nih.gov/pubmed/28095293 http://dx.doi.org/10.7554/eLife.22540 |
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