The MEK-Inhibitor Selumetinib Attenuates Tumor Growth and Reduces IL-6 Expression but Does Not Protect against Muscle Wasting in Lewis Lung Cancer Cachexia

Cachexia, or wasting of skeletal muscle and fat, afflicts many patients with chronic diseases including cancer, organ failure, and AIDS. Muscle wasting reduces quality of life and decreases response to therapy. Cachexia is caused partly by elevated inflammatory cytokines, including interleukin-6 (IL...

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Detalles Bibliográficos
Autores principales: Au, Ernie D., Desai, Aditya P., Koniaris, Leonidas G., Zimmers, Teresa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241300/
https://www.ncbi.nlm.nih.gov/pubmed/28149280
http://dx.doi.org/10.3389/fphys.2016.00682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241300/
https://www.ncbi.nlm.nih.gov/pubmed/28149280
http://dx.doi.org/10.3389/fphys.2016.00682

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