The ERK–ZEB1 pathway mediates epithelial–mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids

High thymidylate synthase (TS) level in cancer tissue is considered to result in resistance to pemetrexed therapy for advanced stages of nonsquamous non-small cell lung cancers. To further investigate the mechanism of pemetrexed resistance and potential prognostic outcomes in lung cancer, we establi...

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Detalles Bibliográficos
Autores principales: Chiu, L-Y, Hsin, I-L, Yang, T-Y, Sung, W-W, Chi, J-Y, Chang, J T, Ko, J-L, Sheu, G-T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241427/
https://www.ncbi.nlm.nih.gov/pubmed/27270426
http://dx.doi.org/10.1038/onc.2016.195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241427/
https://www.ncbi.nlm.nih.gov/pubmed/27270426
http://dx.doi.org/10.1038/onc.2016.195

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