Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays

Idiosyncratic drug-induced liver injury (IDILI) is a significant source of drug recall and acute liver failure (ALF) in the United States. While current drug development processes emphasize general toxicity and drug metabolizing enzyme- (DME-) mediated toxicity, it has been challenging to develop co...

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Detalles Bibliográficos
Autores principales: Roth, Alexander D., Lee, Moo-Yeal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241492/
https://www.ncbi.nlm.nih.gov/pubmed/28133614
http://dx.doi.org/10.1155/2017/9176937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241492/
https://www.ncbi.nlm.nih.gov/pubmed/28133614
http://dx.doi.org/10.1155/2017/9176937

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