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Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

AMP-activated protein kinase (AMPK) plays diverse roles and coordinates complex metabolic pathways for maintenance of energy homeostasis. This could be explained by the fact that AMPK exists as multiple heterotrimer complexes comprising a catalytic α-subunit (α1 and α2) and regulatory β (β1 and β2)-...

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Detalles Bibliográficos
Autores principales: Bultot, Laurent, Jensen, Thomas E., Lai, Yu-Chiang, Madsen, Agnete L. B., Collodet, Caterina, Kviklyte, Samanta, Deak, Maria, Yavari, Arash, Foretz, Marc, Ghaffari, Sahar, Bellahcene, Mohamed, Ashrafian, Houman, Rider, Mark H., Richter, Erik A., Sakamoto, Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241553/
https://www.ncbi.nlm.nih.gov/pubmed/27577855
http://dx.doi.org/10.1152/ajpendo.00237.2016