The Alzheimer's Disease-Associated R47H Variant of TREM2 Has an Altered Glycosylation Pattern and Protein Stability

The R47H coding variant of the triggering receptor expressed on myeloid cells-2 (TREM2) increases the risk of Alzheimer's disease (AD) similar to apolipoprotein E4. TREM2 R47H has recently been shown to have impaired binding to damage-associated lipid or apolipoprotein ligands. However, it is n...

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Detalles Bibliográficos
Autores principales: Park, Ji-Seon, Ji, In Jung, Kim, Dong-Hou, An, Hyun Joo, Yoon, Seung-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241589/
https://www.ncbi.nlm.nih.gov/pubmed/28149270
http://dx.doi.org/10.3389/fnins.2016.00618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241589/
https://www.ncbi.nlm.nih.gov/pubmed/28149270
http://dx.doi.org/10.3389/fnins.2016.00618

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