Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase

Polycyclic tetramate macrolactams (PTMs) were identified as distinct secondary metabolites of the mangrove-derived Streptomyces xiamenensis 318. Together with three known compounds—ikarugamycin (1), capsimycin (2) and capsimycin B (3)—two new compounds, capsimycin C (4) with trans-diols and capsimyc...

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Detalles Bibliográficos
Autores principales: Yu, He-Lin, Jiang, Shu-Heng, Bu, Xu-Liang, Wang, Jia-Hua, Weng, Jing-Yi, Yang, Xiao-Mei, He, Kun-Yan, Zhang, Zhi-Gang, Ao, Ping, Xu, Jun, Xu, Min-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241641/
https://www.ncbi.nlm.nih.gov/pubmed/28098172
http://dx.doi.org/10.1038/srep40689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241641/
https://www.ncbi.nlm.nih.gov/pubmed/28098172
http://dx.doi.org/10.1038/srep40689

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