Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling

Development of mice with hepatocyte knockout of lanosterol 14α-demethylase (H(Cyp51−/−)) from cholesterol synthesis is characterized by the progressive onset of liver injury with ductular reaction and fibrosis. These changes begin during puberty and are generally more aggravated in the knockout fema...

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Detalles Bibliográficos
Autores principales: Urlep, Žiga, Lorbek, Gregor, Perše, Martina, Jeruc, Jera, Juvan, Peter, Matz-Soja, Madlen, Gebhardt, Rolf, Björkhem, Ingemar, Hall, Jason A., Bonneau, Richard, Littman, Dan R., Rozman, Damjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241696/
https://www.ncbi.nlm.nih.gov/pubmed/28098217
http://dx.doi.org/10.1038/srep40775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241696/
https://www.ncbi.nlm.nih.gov/pubmed/28098217
http://dx.doi.org/10.1038/srep40775

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