(−)-Englerin A-evoked Cytotoxicity Is Mediated by Na(+) Influx and Counteracted by Na(+)/K(+)-ATPase

(−)-Englerin A ((−)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing transient receptor potential canonical 4 (TRPC4) protein. Because these channels are Ca(2+)-permeable, it was initially thought that the cytotox...

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Detalles Bibliográficos
Autores principales: Ludlow, Melanie J., Gaunt, Hannah J., Rubaiy, Hussein N., Musialowski, Katie E., Blythe, Nicola M., Vasudev, Naveen S., Muraki, Katsuhiko, Beech, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241745/
https://www.ncbi.nlm.nih.gov/pubmed/27875305
http://dx.doi.org/10.1074/jbc.M116.755678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241745/
https://www.ncbi.nlm.nih.gov/pubmed/27875305
http://dx.doi.org/10.1074/jbc.M116.755678

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