Cargando…

(−)-Englerin A-evoked Cytotoxicity Is Mediated by Na(+) Influx and Counteracted by Na(+)/K(+)-ATPase

(−)-Englerin A ((−)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing transient receptor potential canonical 4 (TRPC4) protein. Because these channels are Ca(2+)-permeable, it was initially thought that the cytotox...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ludlow, Melanie J., Gaunt, Hannah J., Rubaiy, Hussein N., Musialowski, Katie E., Blythe, Nicola M., Vasudev, Naveen S., Muraki, Katsuhiko, Beech, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241745/ https://www.ncbi.nlm.nih.gov/pubmed/27875305 http://dx.doi.org/10.1074/jbc.M116.755678

Ejemplares similares

Na(+) entry through heteromeric TRPC4/C1 channels mediates (−)Englerin A-induced cytotoxicity in synovial sarcoma cells
por: Muraki, Katsuhiko, et al.
Publicado: (2017)

TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A
por: Cheung, Sin Ying, et al.
Publicado: (2018)

Natural and synthetic flavonoid modulation of TRPC5 channels
por: Naylor, Jacqueline, et al.
Publicado: (2016)

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels
por: Rubaiy, Hussein N., et al.
Publicado: (2017)

Potassium ion influx and Na+,K+-ATPase activity are required for the hamster sperm acrosome reaction
Publicado: (1981)

Glutamate-Evoked Ca(2+) Responses in the Rat Suprachiasmatic Nucleus: Involvement of Na(+)/K(+)-ATPase and Na(+)/Ca(2+)-Exchanger
por: Cheng, Pi-Cheng, et al.
Publicado: (2023)

Na(+)/Ca(2+) exchange and Na(+)/K(+)-ATPase in the heart
por: Shattock, Michael J, et al.
Publicado: (2015)

Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease
por: Minard, Aisling, et al.
Publicado: (2018)

Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics
por: Gaunt, Hannah J., et al.
Publicado: (2016)

Kinetics and stoichiometry of coupled Na efflux and Ca influx (Na/Ca exchange) in barnacle muscle cells
Publicado: (1989)

Synthesis and Biological Evaluation of New (−)‐Englerin Analogues
por: López‐Suárez, Laura, et al.
Publicado: (2016)

Kinetics of Na-ATPase activity by the Na,K pump. Interactions of the phosphorylated intermediates with Na+, Tris+, and K+
Publicado: (1983)

β subunit affects Na(+) and K(+) affinities of Na(+)/K(+)-ATPase: Na(+) and K(+) affinities of a hybrid Na(+)/K(+)-ATPase composed of insect α and mammalian β subunits
por: Homareda, Haruo, et al.
Publicado: (2022)

Endogenous Na(+), K(+)-ATPase inhibitors and CSF [Na(+)] contribute to migraine formation
por: Gross, Noah B., et al.
Publicado: (2019)

Cerebral influx of Na(+) and Cl(−) as the osmotherapy-mediated rebound response in rats
por: Oernbo, Eva Kjer, et al.
Publicado: (2018)

Yoda1 analogue (Dooku1) which antagonizes Yoda1‐evoked activation of Piezo1 and aortic relaxation
por: Evans, Elizabeth L, et al.
Publicado: (2018)

C-peptide, Na(+),K(+)-ATPase, and Diabetes
por: Vague, P., et al.
Publicado: (2004)

Tuning of the Na,K-ATPase by the beta subunit
por: Hilbers, Florian, et al.
Publicado: (2016)

Transcriptional regulators of Na,K-ATPase subunits
por: Li, Zhiqin, et al.
Publicado: (2015)

Na(+), K(+)-ATPase Signaling and Bipolar Disorder
por: Lichtstein, David, et al.
Publicado: (2018)

Na/K-ATPase and Regulation of Sperm Function
por: Thundathil, Jacob C., et al.
Publicado: (2018)

The role of Na(+)‐K(+)‐ATPase in the epileptic brain
por: Sun, Jinyi, et al.
Publicado: (2022)

Ultrastructure of Na,K-transport vesicles reconstituted with purified renal Na,K-ATPase
Publicado: (1980)

Glutamate Water Gates in the Ion Binding Pocket of Na(+) Bound Na(+), K(+)-ATPase
por: Han, Minwoo, et al.
Publicado: (2017)

Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy
por: Felippe Gonçalves-de-Albuquerque, Cassiano, et al.
Publicado: (2017)

Na(+)-induced Ca(2+) influx through reverse mode of Na(+)-Ca(2+) exchanger in mouse ventricular cardiomyocyte
por: Yan, Zhen-Yu, et al.
Publicado: (2015)

Na(+)-stimulated ATPase of alkaliphilic halotolerant cyanobacterium Aphanothece halophytica translocates Na(+ )into proteoliposomes via Na(+ )uniport mechanism
por: Soontharapirakkul, Kanteera, et al.
Publicado: (2010)

An ex vivo perfused ventilated murine lung model suggests lack of acute pulmonary toxicity of the potential novel anticancer agent (−)-englerin A
por: Schremmer, Christian, et al.
Publicado: (2022)

Englerin A Selectively Induces Necrosis in Human Renal Cancer Cells
por: Sulzmaier, Florian J., et al.
Publicado: (2012)

Unveiling (−)‐Englerin A as a Modulator of L‐Type Calcium Channels
por: Rodrigues, Tiago, et al.
Publicado: (2016)

Regulation of Cardiac Remodeling by Cardiac Na(+)/K(+)-ATPase Isoforms
por: Liu, Lijun, et al.
Publicado: (2016)

Extracellular Na(+) levels regulate formation and activity of the Na(X)/alpha1-Na(+)/K(+)-ATPase complex in neuronal cells
por: Berret, Emmanuelle, et al.
Publicado: (2014)

Measurements of Na(+)-occluded intermediates during the catalytic cycle of the Na(+)/K(+)-ATPase provide novel insights into the mechanism of Na(+) transport
por: Faraj, Santiago E., et al.
Publicado: (2022)

The Na(+),K(+)-ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state
por: Fruergaard, Marlene U., et al.
Publicado: (2022)

Na+ and K+ transport at basolateral membranes of epithelial cells. I. Stoichiometry of the Na,K-ATPase
Publicado: (1986)

Regulation of Na(+)/K(+) ATPase Transport Velocity by RNA Editing
por: Colina, Claudia, et al.
Publicado: (2010)

Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy
por: Liu, Jiang, et al.
Publicado: (2016)

Structural organization of (Na+ + K+)-ATPase in purified membranes
Publicado: (1984)

The modulation of erythrocyte Na(+)/K(+)-ATPase activity by curcumin
por: Singh, Prabhakar, et al.
Publicado: (2015)

Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase
por: Castillo, Juan P., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_n340bnsm7ants0f2ci91krtsnk