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Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA

The hallmark of Salmonella Typhimurium infection is an acute intestinal inflammatory response, which is mediated through the action of secreted bacterial effector proteins. The pro-inflammatory Salmonella effector SopA is a HECT-like E3 ligase, which was previously proposed to activate host RING lig...

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Detalles Bibliográficos
Autores principales: Fiskin, Evgenij, Bhogaraju, Sagar, Herhaus, Lina, Kalayil, Sissy, Hahn, Marcel, Dikic, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241803/
https://www.ncbi.nlm.nih.gov/pubmed/28084320
http://dx.doi.org/10.1038/ncomms14004