The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor

β-TrCP and SKP2 are two well-studied F-box proteins, which often act as oncogenes. Whether and how they communicate with each other is unknown. Here we report that FBXW2, a poorly characterized F-box, is a substrate of β-TrCP1 and an E3 ligase for SKP2. While β-TrCP1 promotes FBXW2 ubiquitylation an...

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Detalles Bibliográficos
Autores principales: Xu, Jie, Zhou, Weihua, Yang, Fei, Chen, Guoan, Li, Haomin, Zhao, Yongchao, Liu, Pengyuan, Li, Hua, Tan, Mingjia, Xiong, Xiufang, Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241824/
https://www.ncbi.nlm.nih.gov/pubmed/28090088
http://dx.doi.org/10.1038/ncomms14002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241824/
https://www.ncbi.nlm.nih.gov/pubmed/28090088
http://dx.doi.org/10.1038/ncomms14002

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