An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase

The protein microenvironment surrounding the flavin cofactor in flavoenzymes is key to the efficiency and diversity of reactions catalysed by this class of enzymes. X-ray diffraction structures of oxidoreductase flavoenzymes have revealed recurrent features which facilitate catalysis, such as a hydr...

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Detalles Bibliográficos
Autores principales: Golden, Emily, Yu, Li-Juan, Meilleur, Flora, Blakeley, Matthew P., Duff, Anthony P., Karton, Amir, Vrielink, Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241826/
https://www.ncbi.nlm.nih.gov/pubmed/28098177
http://dx.doi.org/10.1038/srep40517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241826/
https://www.ncbi.nlm.nih.gov/pubmed/28098177
http://dx.doi.org/10.1038/srep40517

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