Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase

Human NAD-dependent isocitrate dehydrogenase catalyzes the decarboxylation of isocitrate (ICT) into α-ketoglutarate in the Krebs cycle. It exists as the α(2)βγ heterotetramer composed of the αβ and αγ heterodimers. Previously, we have demonstrated biochemically that the α(2)βγ heterotetramer and αγ...

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Detalles Bibliográficos
Autores principales: Ma, Tengfei, Peng, Yingjie, Huang, Wei, Ding, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241874/
https://www.ncbi.nlm.nih.gov/pubmed/28098230
http://dx.doi.org/10.1038/srep40921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241874/
https://www.ncbi.nlm.nih.gov/pubmed/28098230
http://dx.doi.org/10.1038/srep40921

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