TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor (BMPR-II) gene underlie heritable pulmonary arterial hypertension (HPAH). Although inflammation promotes PAH, the mechanisms by which inflammation and BMPR-II dysfunction conspire to cause disease remain unknown. Her...

Descripción completa

Detalles Bibliográficos
Autores principales: Hurst, Liam A., Dunmore, Benjamin J., Long, Lu, Crosby, Alexi, Al-Lamki, Rafia, Deighton, John, Southwood, Mark, Yang, Xudong, Nikolic, Marko Z., Herrera, Blanca, Inman, Gareth J., Bradley, John R., Rana, Amer A., Upton, Paul D., Morrell, Nicholas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241886/
https://www.ncbi.nlm.nih.gov/pubmed/28084316
http://dx.doi.org/10.1038/ncomms14079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241886/
https://www.ncbi.nlm.nih.gov/pubmed/28084316
http://dx.doi.org/10.1038/ncomms14079

Ejemplares similares