A novel thiophene‐3‐carboxamide analog of annonaceous acetogenin exhibits antitumor activity via inhibition of mitochondrial complex I

Previously we synthesized JCI‐20679, a novel thiophene‐3‐carboxamide analog of annonaceous acetogenins which have shown potent antitumor activity, with no serious side effects, in mouse xenograft models. In this study, we investigated the antitumor mechanism of JCI‐20679. The growth inhibition profi...

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Detalles Bibliográficos
Autores principales: Akatsuka, Akinobu, Kojima, Naoto, Okamura, Mutsumi, Dan, Shingo, Yamori, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242172/
https://www.ncbi.nlm.nih.gov/pubmed/28116099
http://dx.doi.org/10.1002/prp2.246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242172/
https://www.ncbi.nlm.nih.gov/pubmed/28116099
http://dx.doi.org/10.1002/prp2.246

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