LIN‐28 balances longevity and germline stem cell number in Caenorhabditis elegans through let‐7/AKT/DAF‐16 axis

The RNA‐binding protein LIN‐28 was first found to control developmental timing in Caenorhabditis elegans. Later, it was found to play important roles in pluripotency, metabolism, and cancer in mammals. Here we report that a low dosage of lin‐28 enhanced stress tolerance and longevity, and reduced ge...

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Detalles Bibliográficos
Autores principales: Wang, Dan, Hou, Lei, Nakamura, Shuhei, Su, Ming, Li, Fang, Chen, Weiyang, Yan, Yizhen, Green, Christopher D., Chen, Di, Zhang, Hong, Antebi, Adam, Han, Jing‐Dong J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242300/
https://www.ncbi.nlm.nih.gov/pubmed/27730721
http://dx.doi.org/10.1111/acel.12539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242300/
https://www.ncbi.nlm.nih.gov/pubmed/27730721
http://dx.doi.org/10.1111/acel.12539

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