Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age‐associated functional decline

Heart performance declines with age. Impaired protein quality control (PQC), due to reduced ubiquitin‐proteasome system (UPS) activity, autophagic function, and/or chaperone‐mediated protein refolding, contributes to cardiac deterioration. The transcription factor FOXO participates in regulating gen...

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Detalles Bibliográficos
Autores principales: Blice‐Baum, Anna C., Zambon, Alexander C., Kaushik, Gaurav, Viswanathan, Meera C., Engler, Adam J., Bodmer, Rolf, Cammarato, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242305/
https://www.ncbi.nlm.nih.gov/pubmed/28090761
http://dx.doi.org/10.1111/acel.12543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242305/
https://www.ncbi.nlm.nih.gov/pubmed/28090761
http://dx.doi.org/10.1111/acel.12543

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