Cargando…

Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age‐associated functional decline

Heart performance declines with age. Impaired protein quality control (PQC), due to reduced ubiquitin‐proteasome system (UPS) activity, autophagic function, and/or chaperone‐mediated protein refolding, contributes to cardiac deterioration. The transcription factor FOXO participates in regulating gen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blice‐Baum, Anna C., Zambon, Alexander C., Kaushik, Gaurav, Viswanathan, Meera C., Engler, Adam J., Bodmer, Rolf, Cammarato, Anthony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242305/ https://www.ncbi.nlm.nih.gov/pubmed/28090761 http://dx.doi.org/10.1111/acel.12543

Ejemplares similares

Cardiac-Restricted Expression of VCP/TER94 RNAi or Disease Alleles Perturbs Drosophila Heart Structure and Impairs Function
por: Viswanathan, Meera C., et al.
Publicado: (2016)

Pseudo-acetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performance
por: Viswanathan, Meera C., et al.
Publicado: (2015)

Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction
por: Kaushik, Gaurav, et al.
Publicado: (2012)

FOXO1 deficiency impairs proteostasis in aged T cells
por: Jin, Jun, et al.
Publicado: (2020)

Maintaining proteostasis under mechanical stress
por: Höhfeld, Jörg, et al.
Publicado: (2021)

Cellular proteostasis decline in human senescence
por: Montague-Cardoso, Karli
Publicado: (2021)

Cellular proteostasis decline in human senescence
por: Sabath, Niv, et al.
Publicado: (2020)

The aging proteostasis decline: From nematode to human
por: Meller, Anatoly, et al.
Publicado: (2021)

A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging
por: Nishimura, Mayuko, et al.
Publicado: (2014)

Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity
por: Pokrzywa, Wojciech, et al.
Publicado: (2017)

Secretory autophagy maintains proteostasis upon lysosome inhibition
por: Solvik, Tina A., et al.
Publicado: (2022)

The Role of Exercise in Maintaining Mitochondrial Proteostasis in Parkinson’s Disease
por: Li, Jingwen, et al.
Publicado: (2023)

Sizing up models of heart failure: Proteomics from flies to humans
por: Kooij, Viola, et al.
Publicado: (2014)

Multi-modal and multiscale imaging approaches reveal novel cardiovascular pathophysiology in Drosophila melanogaster
por: Weismann, Constance G., et al.
Publicado: (2019)

Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila
por: Bai, Hua, et al.
Publicado: (2013)

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal
por: Jose, Lorena Hidalgo San, et al.
Publicado: (2020)

The struggle by Caenorhabditis elegans to maintain proteostasis during aging and disease
por: Kikis, Elise A.
Publicado: (2016)

Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis
por: Ferreira, Joao Vasco, et al.
Publicado: (2019)

Biophysical characterization of G-quadruplex forming FMR1 mRNA and of its interactions with different fragile X mental retardation protein isoforms
por: Blice-Baum, Anna C., et al.
Publicado: (2014)

Expression patterns of cardiac aging in Drosophila
por: Cannon, Leah, et al.
Publicado: (2017)

The R369 Myosin Residue within Loop 4 Is Critical for Actin Binding and Muscle Function in Drosophila
por: Trujillo, Adriana S., et al.
Publicado: (2022)

The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae
por: Josefson, Rebecca, et al.
Publicado: (2023)

The UPR Maintains Proteostasis and the Viability and Function of Hippocampal Neurons in Adult Mice
por: Liu, Pingting, et al.
Publicado: (2023)

FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells
por: Audesse, Amanda J., et al.
Publicado: (2019)

PM(2.5) and Kidney Function: Long-Term Exposures May Lead to Modest Declines
por: Seltenrich, Nate
Publicado: (2016)

Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression
por: Wang, Xiaofei, et al.
Publicado: (2016)

The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system
por: Shrestha, Amit, et al.
Publicado: (2019)

Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis
por: Ho, Chi-ting, et al.
Publicado: (2019)

Enzymes degraded under high light maintain proteostasis by transcriptional regulation in Arabidopsis
por: Li, Lei, et al.
Publicado: (2022)

Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells
por: Greenwood, Mingkwan, et al.
Publicado: (2022)

Collagen VII maintains proteostasis in dermal fibroblasts by scaffolding TANGO1 cargo
por: Cao, Qingqing, et al.
Publicado: (2022)

Cell surface protein aggregation triggers endocytosis to maintain plasma membrane proteostasis
por: Paul, David, et al.
Publicado: (2023)

Emerging role of UFMylation in secretory cells involved in the endocrine system by maintaining ER proteostasis
por: Cheng, Yun, et al.
Publicado: (2023)

Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects
por: Chen, Holly Y, et al.
Publicado: (2023)

Doctors Should Not Be so Modest
Publicado: (1896)

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy
por: Viswanathan, Meera C., et al.
Publicado: (2017)

Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis
por: Zou, Qianxing, et al.
Publicado: (2021)

The CKS1/CKS2 Proteostasis Axis Is Crucial to Maintain Hematopoietic Stem Cell Function
por: Grey, William, et al.
Publicado: (2023)

RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells
por: Herrejon Chavez, Florisela, et al.
Publicado: (2023)

The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging
por: Francisco, Stephany, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m6opto8vpp7eqagv41m71kppo7