Variation of free‐energy landscape of the p53 C‐terminal domain induced by acetylation: Enhanced conformational sampling

The C‐terminal domain (CTD) of tumor suppressor protein p53 is an intrinsically disordered region that binds to various partner proteins, where lysine of CTD is acetylated/nonacetylated and histidine neutralized/non‐neutralized. Because of the flexibility of the unbound CTD, a free‐energy landscape...

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Detalles Bibliográficos
Autores principales: Iida, Shinji, Mashimo, Tadaaki, Kurosawa, Takashi, Hojo, Hironobu, Muta, Hiroya, Goto, Yuji, Fukunishi, Yoshifumi, Nakamura, Haruki, Higo, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242334/
https://www.ncbi.nlm.nih.gov/pubmed/27735058
http://dx.doi.org/10.1002/jcc.24494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242334/
https://www.ncbi.nlm.nih.gov/pubmed/27735058
http://dx.doi.org/10.1002/jcc.24494

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