The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals

BACKGROUND: Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals. In non-mammalian species, only one xenosensor gene has been found. Using chicken as a model organism, the aim of...

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Detalles Bibliográficos
Autores principales: Handschin, Christoph, Blättler, Sharon, Roth, Adrian, Looser, Renate, Oscarson, Mikael, Kaufmann, Michel R, Podvinec, Michael, Gnerre, Carmela, Meyer, Urs A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524364/
https://www.ncbi.nlm.nih.gov/pubmed/15479477
http://dx.doi.org/10.1186/1478-1336-2-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524364/
https://www.ncbi.nlm.nih.gov/pubmed/15479477
http://dx.doi.org/10.1186/1478-1336-2-7

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