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Generation of α-1,3-galactosyltransferase knocked-out transgenic cloned pigs with knocked-in five human genes
Recent progress in genetic manipulation of pigs designated for xenotransplantation ha6s shown considerable promise on xenograft survival in primates. However, genetic modification of multiple genes in donor pigs by knock-out and knock-in technologies, aiming to enhance immunological tolerance agains...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243873/ https://www.ncbi.nlm.nih.gov/pubmed/27554374 http://dx.doi.org/10.1007/s11248-016-9979-8 |