Predicting Drug Combination Index and Simulating the Network-Regulation Dynamics by Mathematical Modeling of Drug-Targeted EGFR-ERK Signaling Pathway

Synergistic drug combinations enable enhanced therapeutics. Their discovery typically involves the measurement and assessment of drug combination index (CI), which can be facilitated by the development and applications of in-silico CI predictive tools. In this work, we developed and tested the abili...

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Detalles Bibliográficos
Autores principales: Huang, Lu, Jiang, Yuyang, Chen, Yuzong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244366/
https://www.ncbi.nlm.nih.gov/pubmed/28102344
http://dx.doi.org/10.1038/srep40752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244366/
https://www.ncbi.nlm.nih.gov/pubmed/28102344
http://dx.doi.org/10.1038/srep40752

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