Methyl-Cytosine-Driven Structural Changes Enhance Adduction Kinetics of an Exon 7 fragment of the p53 Gene

Methylation of cytosine (C) at C-phosphate-guanine (CpG) sites enhances reactivity of DNA towards electrophiles. Mutations at CpG sites on the p53 tumor suppressor gene that can result from these adductions are in turn correlated with specific cancers. Here we describe the first restriction-enzyme-a...

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Detalles Bibliográficos
Autores principales: Malla, Spundana, Kadimisetty, Karteek, Fu, You-Jun, Choudhary, Dharamainder, Schenkman, John B., Rusling, James F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244379/
https://www.ncbi.nlm.nih.gov/pubmed/28102315
http://dx.doi.org/10.1038/srep40890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244379/
https://www.ncbi.nlm.nih.gov/pubmed/28102315
http://dx.doi.org/10.1038/srep40890

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