Forebrain‐Specific Transgene Rescue of 11β‐HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain‐Derived Neurotrophic Factor mRNA Levels in Aged 11β‐HSD1 Deficient Mice

Mice lacking the intracellular glucocorticoid‐regenerating enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) are protected from age‐related spatial memory deficits. 11β‐HSD1 is expressed predominantly in the brain, liver and adipose tissue. Reduced glucocorticoid levels in the brain in the a...

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Detalles Bibliográficos
Autores principales: Caughey, S., Harris, A. P., Seckl, J. R., Holmes, M. C., Yau, J. L. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244685/
https://www.ncbi.nlm.nih.gov/pubmed/27859809
http://dx.doi.org/10.1111/jne.12447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244685/
https://www.ncbi.nlm.nih.gov/pubmed/27859809
http://dx.doi.org/10.1111/jne.12447

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