Cargando…

Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins

Using a high throughput screening methodology we surveyed a collection of largely uncharacterized validated or suspected kinase inhibitors for anti-human cytomegalovirus (HCMV) activity. From this screen we identified three structurally related 5-aminopyrazine compounds (XMD7-1, -2 and -27) that inh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beelontally, Rooksarr, Wilkie, Gavin S., Lau, Betty, Goodmaker, Charles J., Ho, Catherine M.K., Swanson, Chad M., Deng, Xianming, Wang, Jinhua, Gray, Nathanael S., Davison, Andrew J., Strang, Blair L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244968/ https://www.ncbi.nlm.nih.gov/pubmed/27956134 http://dx.doi.org/10.1016/j.antiviral.2016.12.006

Ejemplares similares

Strain-Dependent Restriction of Human Cytomegalovirus by Zinc Finger Antiviral Proteins
por: Lista, Maria Jose, et al.
Publicado: (2023)

Cross-Species Analysis of Innate Immune Antagonism by Cytomegalovirus IE1 Protein
por: Rothemund, Franziska, et al.
Publicado: (2022)

Human Cytomegalovirus Genomes Survive Mitosis via the IE19 Chromatin-Tethering Domain
por: Lyon, Shelby M., et al.
Publicado: (2020)

Analysis of Human Cytomegalovirus-Encoded SUMO Targets and Temporal Regulation of SUMOylation of the Immediate-Early Proteins IE1 and IE2 during Infection
por: Kim, Eui Tae, et al.
Publicado: (2014)

Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells
por: Ho, Catherine M. K., et al.
Publicado: (2016)

Human cytomegalovirus: taking the strain
por: Wilkinson, Gavin W. G., et al.
Publicado: (2015)

Identification and characterization of bisbenzimide compounds that inhibit human cytomegalovirus replication
por: Falci Finardi, Nicole, et al.
Publicado: (2021)

Impact of Sequence Variation in the UL128 Locus on Production of Human Cytomegalovirus in Fibroblast and Epithelial Cells
por: Murrell, Isa, et al.
Publicado: (2013)

Non-covalent Interaction With SUMO Enhances the Activity of Human Cytomegalovirus Protein IE1
por: Tripathi, Vasvi, et al.
Publicado: (2021)

Human Cytomegalovirus-IE2 Affects Embryonic Liver Development and Survival in Transgenic Mouse
por: Zhang, Xianjuan, et al.
Publicado: (2022)

Genetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during Culture In Vitro
por: Murrell, Isa, et al.
Publicado: (2016)

Human Cytomegalovirus IE2 Disrupts Neural Progenitor Development and Induces Microcephaly in Transgenic Mouse
por: Niu, Delei, et al.
Publicado: (2023)

Oral microbiomes of patients with infective endocarditis (IE): a comparative pilot study of IE patients, patients at risk for IE and healthy controls
por: Mougeot, Jean-Luc C., et al.
Publicado: (2022)

Direct Nanopore Sequencing of Human Cytomegalovirus Genomes from High-Viral-Load Clinical Samples
por: Li, Kathy K., et al.
Publicado: (2023)

Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome
por: Fang, Qianglin, et al.
Publicado: (2016)

Correction: Human cytomegalovirus IE1 alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome
por: Fang, Qianglin, et al.
Publicado: (2016)

Human Cytomegalovirus IE2 Both Activates and Represses Initiation and Modulates Elongation in a Context-Dependent Manner
por: Ball, Christopher B., et al.
Publicado: (2022)

Detection of Human cytomegalovirus UL55 Gene and IE/E Protein Expression in Colorectal Cancer Patients in Egypt
por: Raouf, May, et al.
Publicado: (2023)

Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data
por: Strang, Blair L., et al.
Publicado: (2018)

Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54
por: Strang, Blair L., et al.
Publicado: (2010)

Host Cell Nucleolin Is Required To Maintain the Architecture of Human Cytomegalovirus Replication Compartments
por: Strang, Blair L., et al.
Publicado: (2012)

Protective CD8+ T-cell responses to cytomegalovirus driven by rAAV/GFP/IE1 loading of dendritic cells
por: Yu, Yuefei, et al.
Publicado: (2008)

The Cellular Protein MCM3AP Is Required for Inhibition of Cellular DNA Synthesis by the IE86 Protein of Human Cytomegalovirus
por: Poole, Emma, et al.
Publicado: (2012)

Evaluation of applying IHC4 as a prognostic model in the translational study of Intergroup Exemestane Study (IES): PathIES
por: Cheang, M. C. U., et al.
Publicado: (2017)

Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase
por: Liu, Xi-Juan, et al.
Publicado: (2017)

IE-7919. Reticencias vacunales COVID-19
por: Moreno, M.C. Gómez, et al.
Publicado: (2022)

Sobre las íes : antología personal /
por: Deniz, Gerardo, 1934-2014
Publicado: (2008)

Interaction Network of Proteins Associated with Human Cytomegalovirus IE2-p86 Protein during Infection: A Proteomic Analysis
por: Du, Guixin, et al.
Publicado: (2013)

The Carboxy Terminal Region of the Human Cytomegalovirus Immediate Early 1 (IE1) Protein Disrupts Type II Inteferon Signaling
por: Raghavan, Bindu, et al.
Publicado: (2014)

Crystal Structure of Cytomegalovirus IE1 Protein Reveals Targeting of TRIM Family Member PML via Coiled-Coil Interactions
por: Scherer, Myriam, et al.
Publicado: (2014)

Characteristics of Immediate-Early 2 (IE2) and UL84 Proteins in UL84-Independent Strains of Human Cytomegalovirus (HCMV)
por: Manska, Salome, et al.
Publicado: (2021)

Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection
por: Rodríguez-Martín, Sara, et al.
Publicado: (2012)

Association of human cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44
por: Strang, Blair L., et al.
Publicado: (2010)

Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on “The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts”
por: Mercorelli, Beatrice, et al.
Publicado: (2019)

The effect of murine cytomegalovirus IE-3 specific shRNA is dependent on intragenic target site due to multiple transcription initiation sites
por: Marshall, Brendan, et al.
Publicado: (2011)

Human cytomegalovirus IE1 promoter/enhancer drives variable gene expression in all fiber types in transgenic mouse skeletal muscle
por: Hallauer, Patricia L, et al.
Publicado: (2000)

The Major Immediate-Early Protein IE2 of Human Cytomegalovirus Is Sufficient to Induce Proteasomal Degradation of CD83 on Mature Dendritic Cells
por: Heilingloh, Christiane S., et al.
Publicado: (2017)

An Early Immediate Early Protein IE-1–Specific T-Cell Polyfunctionality Is Associated With a Better Control of Cytomegalovirus Reactivation in Kidney Transplantation
por: Dekeyser, Manon, et al.
Publicado: (2017)

EVOLUTION OF DISEASES i.e. SAMPRAPTI VIGNANA
por: Thakar, V. J.
Publicado: (1981)

Limited replication of human cytomegalovirus in a trophoblast cell line
por: Hyde, Kadeem, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_70vq0moiv9i8gcavjitbitr283