Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D(3 )receptor

BACKGROUND: Our aim was to determine if pramipexole, a D(3 )preferring agonist, effectively reduced dopamine neuron and fiber loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model when given at intraperitoneal doses corresponding to clinical doses. We also determined whether su...

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Detalles Bibliográficos
Autores principales: Joyce, Jeffrey N, Woolsey, Cheryl, Ryoo, Han, Borwege, Sabine, Hagner, Diane
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524509/
https://www.ncbi.nlm.nih.gov/pubmed/15473914
http://dx.doi.org/10.1186/1741-7007-2-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC524509/
https://www.ncbi.nlm.nih.gov/pubmed/15473914
http://dx.doi.org/10.1186/1741-7007-2-22

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