Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells

Uridine-cytidine kinase 2 is an enzyme that is overexpressed in abnormal cell growth and its implication is considered a hallmark of cancer. Due to the selective expression of UCK2 in cancer cells, a selective inhibition of this key enzyme necessitates the discovery of its potential inhibitors for c...

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Detalles Bibliográficos
Autores principales: Malami, Ibrahim, Abdul, Ahmad Bustamam, Abdullah, Rasedee, Kassim, Nur Kartinee Bt, Rosli, Rozita, Yeap, Swee Keong, Waziri, Peter, Etti, Imaobong Christopher, Bello, Muhammad Bashir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245823/
https://www.ncbi.nlm.nih.gov/pubmed/28103302
http://dx.doi.org/10.1371/journal.pone.0170233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245823/
https://www.ncbi.nlm.nih.gov/pubmed/28103302
http://dx.doi.org/10.1371/journal.pone.0170233

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