Two subunits of human ORC are dispensable for DNA replication and proliferation

The six-subunit Origin Recognition Complex (ORC) is believed to be an essential eukaryotic ATPase that binds to origins of replication as a ring-shaped heterohexamer to load MCM2-7 and initiate DNA replication. We have discovered that human cell lines in culture proliferate with intact chromosomal o...

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Detalles Bibliográficos
Autores principales: Shibata, Etsuko, Kiran, Manjari, Shibata, Yoshiyuki, Singh, Samarendra, Kiran, Shashi, Dutta, Anindya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245961/
https://www.ncbi.nlm.nih.gov/pubmed/27906128
http://dx.doi.org/10.7554/eLife.19084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245961/
https://www.ncbi.nlm.nih.gov/pubmed/27906128
http://dx.doi.org/10.7554/eLife.19084

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