A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity

Tumour radiotherapy resistance involves the cell cycle pathway. CDC25 phosphatases are key cell cycle regulators. However, how CDC25 activity is precisely controlled remains largely unknown. Here, we show that LIM domain-containing proteins, such as FHL1, increase inhibitory CDC25 phosphorylation by...

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Detalles Bibliográficos
Autores principales: Xu, Xiaojie, Fan, Zhongyi, Liang, Chaoyang, Li, Ling, Wang, Lili, Liang, Yingchun, Wu, Jun, Chang, Shaohong, Yan, Zhifeng, Lv, Zhaohui, Fu, Jing, Liu, Yang, Jin, Shuai, Wang, Tao, Hong, Tian, Dong, Yishan, Ding, Lihua, Cheng, Long, Liu, Rui, Fu, Shenbo, Jiao, Shunchang, Ye, Qinong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247581/
https://www.ncbi.nlm.nih.gov/pubmed/28094252
http://dx.doi.org/10.1038/ncomms14059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247581/
https://www.ncbi.nlm.nih.gov/pubmed/28094252
http://dx.doi.org/10.1038/ncomms14059

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