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GLP-1R Signaling Directly Activates Arcuate Nucleus Kisspeptin Action in Brain Slices but Does not Rescue Luteinizing Hormone Inhibition in Ovariectomized Mice During Negative Energy Balance

Kisspeptin (Kiss1) neurons in the hypothalamic arcuate nucleus (ARC) are key components of the hypothalamic-pituitary-gonadal axis, as they regulate the basal pulsatile release of gonadotropin releasing hormone (GnRH). ARC Kiss1 action is dependent on energy status, and unmasking metabolic factors r...

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Detalles Bibliográficos
Autores principales: Heppner, Kristy M., Baquero, Arian F., Bennett, Camdin M., Lindsley, Sarah R., Kirigiti, Melissa A., Bennett, Baylin, Bosch, Martha A., Mercer, Aaron J., Rønnekleiv, Oline K., True, Cadence, Grove, Kevin L., Smith, M. Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247618/
https://www.ncbi.nlm.nih.gov/pubmed/28144621
http://dx.doi.org/10.1523/ENEURO.0198-16.2016