Pharmacological characterisation of the highly Na(V)1.7 selective spider venom peptide Pn3a

Human genetic studies have implicated the voltage-gated sodium channel Na(V)1.7 as a therapeutic target for the treatment of pain. A novel peptide, μ-theraphotoxin-Pn3a, isolated from venom of the tarantula Pamphobeteus nigricolor, potently inhibits Na(V)1.7 (IC(50) 0.9 nM) with at least 40–1000-fol...

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Detalles Bibliográficos
Autores principales: Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N., Vetter, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247677/
https://www.ncbi.nlm.nih.gov/pubmed/28106092
http://dx.doi.org/10.1038/srep40883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247677/
https://www.ncbi.nlm.nih.gov/pubmed/28106092
http://dx.doi.org/10.1038/srep40883

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