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Endoplasmic Reticulum Oxidative Stress Triggers Tgf-Beta-Dependent Muscle Dysfunction by Accelerating Ascorbic Acid Turnover

Endoplasmic reticulum (ER) and oxidative stress are two related phenomena that have important metabolic consequences. As many skeletal muscle diseases are triggered by oxidative stress, we explored the chain of events linking a hyperoxidized ER (which causes ER and oxidative stress) with skeletal mu...

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Detalles Bibliográficos
Autores principales: Pozzer, Diego, Favellato, Mariagrazia, Bolis, Marco, Invernizzi, Roberto William, Solagna, Francesca, Blaauw, Bert, Zito, Ester
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247721/
https://www.ncbi.nlm.nih.gov/pubmed/28106121
http://dx.doi.org/10.1038/srep40993