TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells, and protects mice from lethal influenza infection

Dysregulated Toll-like receptor (TLR)-4 activation is involved in acute systemic sepsis, chronic inflammatory diseases, such as atherosclerosis and diabetes, and in viral infections, such as influenza infection. Thus, therapeutic control of the TLR4 signalling pathway is of major interest. Here we t...

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Detalles Bibliográficos
Autores principales: Perrin-Cocon, Laure, Aublin-Gex, Anne, Sestito, Stefania E., Shirey, Kari Ann, Patel, Mira C., André, Patrice, Blanco, Jorge C., Vogel, Stefanie N., Peri, Francesco, Lotteau, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247753/
https://www.ncbi.nlm.nih.gov/pubmed/28106157
http://dx.doi.org/10.1038/srep40791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247753/
https://www.ncbi.nlm.nih.gov/pubmed/28106157
http://dx.doi.org/10.1038/srep40791

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