Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage

Chk1 kinase inhibitors are currently under clinical investigation as potentiators of cytotoxic chemotherapy and demonstrate potent activity in combination with anti-metabolite drugs that increase replication stress through the inhibition of nucleotide or deoxyribonucleotide biosynthesis. Inhibiting...

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Detalles Bibliográficos
Autor principal: Massey, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247758/
https://www.ncbi.nlm.nih.gov/pubmed/28106079
http://dx.doi.org/10.1038/srep40778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247758/
https://www.ncbi.nlm.nih.gov/pubmed/28106079
http://dx.doi.org/10.1038/srep40778

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