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Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage
Chk1 kinase inhibitors are currently under clinical investigation as potentiators of cytotoxic chemotherapy and demonstrate potent activity in combination with anti-metabolite drugs that increase replication stress through the inhibition of nucleotide or deoxyribonucleotide biosynthesis. Inhibiting...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247758/ https://www.ncbi.nlm.nih.gov/pubmed/28106079 http://dx.doi.org/10.1038/srep40778 |