An oxygen sensitive self-decision making engineered CAR T-cell

A key to the success of chimeric antigen receptor (CAR) T-cell based therapies greatly rely on the capacity to identify and target antigens with expression restrained to tumor cells. Here we present a strategy to generate CAR T-cells that are only effective locally (tumor tissue), potentially also i...

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Detalles Bibliográficos
Autores principales: Juillerat, Alexandre, Marechal, Alan, Filhol, Jean Marie, Valogne, Yannick, Valton, Julien, Duclert, Aymeric, Duchateau, Philippe, Poirot, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247770/
https://www.ncbi.nlm.nih.gov/pubmed/28106050
http://dx.doi.org/10.1038/srep39833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247770/
https://www.ncbi.nlm.nih.gov/pubmed/28106050
http://dx.doi.org/10.1038/srep39833

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