Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling

BACKGROUND: LRRK2 mutations and risk variants increase susceptibility to inherited and idiopathic Parkinson’s disease, while recent studies have identified potential protective variants. This, and the fact that LRRK2 mutation carriers develop symptoms and brain pathology almost indistinguishable fro...

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Detalles Bibliográficos
Autores principales: Berwick, Daniel C., Javaheri, Behzad, Wetzel, Andrea, Hopkinson, Mark, Nixon-Abell, Jonathon, Grannò, Simone, Pitsillides, Andrew A., Harvey, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248453/
https://www.ncbi.nlm.nih.gov/pubmed/28103901
http://dx.doi.org/10.1186/s13024-017-0153-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248453/
https://www.ncbi.nlm.nih.gov/pubmed/28103901
http://dx.doi.org/10.1186/s13024-017-0153-4

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