Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

Treatment of BRAF‐mutant melanomas with MAP kinase pathway inhibitors is paradigmatic of the promise of precision cancer therapy but also highlights problems with drug resistance that limit patient benefit. We use live‐cell imaging, single‐cell analysis, and molecular profiling to show that exposure...

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Detalles Bibliográficos
Autores principales: Fallahi‐Sichani, Mohammad, Becker, Verena, Izar, Benjamin, Baker, Gregory J, Lin, Jia‐Ren, Boswell, Sarah A, Shah, Parin, Rotem, Asaf, Garraway, Levi A, Sorger, Peter K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248573/
https://www.ncbi.nlm.nih.gov/pubmed/28069687
http://dx.doi.org/10.15252/msb.20166796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248573/
https://www.ncbi.nlm.nih.gov/pubmed/28069687
http://dx.doi.org/10.15252/msb.20166796

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