Species-specific pharmacology of maximakinin, an amphibian homologue of bradykinin: putative prodrug activity at the human B(2) receptor and peptidase resistance in rats

Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B(2) receptor (B(2)R) agonist eliciting prolonged signaling. We reinvestigated this 19-mer for species-specific pharmacologic profile, in vivo confirmation of resistance to inactivation by angiotens...

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Detalles Bibliográficos
Autores principales: Charest-Morin, Xavier, Bachelard, Hélène, Jean, Melissa, Marceau, Francois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2017
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248581/
https://www.ncbi.nlm.nih.gov/pubmed/28133580
http://dx.doi.org/10.7717/peerj.2911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248581/
https://www.ncbi.nlm.nih.gov/pubmed/28133580
http://dx.doi.org/10.7717/peerj.2911

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