hZnT8 (Slc30a8) Transgenic Mice That Overexpress the R325W Polymorph Have Reduced Islet Zn(2+) and Proinsulin Levels, Increased Glucose Tolerance After a High-Fat Diet, and Altered Levels of Pancreatic Zinc Binding Proteins

Zinc (Zn(2+)) is involved in both type 1 diabetes (T1DM) and type 2 diabetes (T2DM). The wild-type (WT) form of the β-cell–specific Zn(2+) transporter, ZNT8, is linked to T2DM susceptibility. ZnT8 null mice have a mild phenotype with a slight decrease in glucose tolerance, whereas patients with the...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Li, Bai, Shi, Sheline, Christian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248993/
https://www.ncbi.nlm.nih.gov/pubmed/27899481
http://dx.doi.org/10.2337/db16-0323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248993/
https://www.ncbi.nlm.nih.gov/pubmed/27899481
http://dx.doi.org/10.2337/db16-0323

Ejemplares similares