Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation

Inhibition of the tankyrase enzymes (TNKS1 and TNKS2) has recently been shown to induce highly dynamic assemblies of β-catenin destruction complex components known as degradasomes, which promote degradation of β-catenin and reduced Wnt signaling activity in colorectal cancer cells. AXIN1 and AXIN2/C...

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Detalles Bibliográficos
Autores principales: Thorvaldsen, Tor Espen, Pedersen, Nina Marie, Wenzel, Eva Maria, Stenmark, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249069/
https://www.ncbi.nlm.nih.gov/pubmed/28107521
http://dx.doi.org/10.1371/journal.pone.0170508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249069/
https://www.ncbi.nlm.nih.gov/pubmed/28107521
http://dx.doi.org/10.1371/journal.pone.0170508

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