Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function

The adapter protein SLP76 is a key orchestrator of T cell receptor (TCR) signal transduction. We previously identified a negative feedback loop that modulates T cell activation, involving phosphorylation of Ser376 of SLP76 by the hematopoietic progenitor kinase 1 (HPK1). However, the physiological r...

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Detalles Bibliográficos
Autores principales: Navas, Victor H., Cuche, Céline, Alcover, Andres, Di Bartolo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249077/
https://www.ncbi.nlm.nih.gov/pubmed/28107427
http://dx.doi.org/10.1371/journal.pone.0170396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249077/
https://www.ncbi.nlm.nih.gov/pubmed/28107427
http://dx.doi.org/10.1371/journal.pone.0170396

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