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PI3K and MAPK pathways mediate the BDNF/TrkB-increased metastasis in neuroblastoma

Brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor TrkB have been reported to be associated with poor prognosis in neuroblastoma (NB) patients. Our previous studies indicated that BDNF activation of TrkB induces chemo-resistance through activation of phosphoinositide-3-kinase...

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Detalles Bibliográficos
Autores principales: Hua, Zhongyan, Gu, Xiao, Dong, Yudi, Tan, Fei, Liu, Zhihui, Thiele, Carol J., Li, Zhijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250655/
https://www.ncbi.nlm.nih.gov/pubmed/27752996
http://dx.doi.org/10.1007/s13277-016-5433-z