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Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?
The occurrence of high rates of somatic mutations in cancer is believed to correspond to increased frequency of neo-epitope formation and tumor immunogenicity. Thus, classification of patients with cancer according to degree a somatic hyper-mutational status could be proposed as a predictive biomark...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251272/ https://www.ncbi.nlm.nih.gov/pubmed/28109293 http://dx.doi.org/10.1186/s12967-017-1119-6 |