Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?

The occurrence of high rates of somatic mutations in cancer is believed to correspond to increased frequency of neo-epitope formation and tumor immunogenicity. Thus, classification of patients with cancer according to degree a somatic hyper-mutational status could be proposed as a predictive biomark...

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Autores principales: Palmieri, Giuseppe, Colombino, Maria, Cossu, Antonio, Marchetti, Antonio, Botti, Gerardo, Ascierto, Paolo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251272/
https://www.ncbi.nlm.nih.gov/pubmed/28109293
http://dx.doi.org/10.1186/s12967-017-1119-6
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author Palmieri, Giuseppe
Colombino, Maria
Cossu, Antonio
Marchetti, Antonio
Botti, Gerardo
Ascierto, Paolo A.
author_facet Palmieri, Giuseppe
Colombino, Maria
Cossu, Antonio
Marchetti, Antonio
Botti, Gerardo
Ascierto, Paolo A.
author_sort Palmieri, Giuseppe
collection PubMed
description The occurrence of high rates of somatic mutations in cancer is believed to correspond to increased frequency of neo-epitope formation and tumor immunogenicity. Thus, classification of patients with cancer according to degree a somatic hyper-mutational status could be proposed as a predictive biomarker of responsiveness to immunotherapy with immune checkpoint inhibitors. Here, we discuss the suitable and reliable tests easily adoptable in clinical practice to assess somatic mutational status in patients with advanced cancer.
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spelling pubmed-52512722017-01-26 Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy? Palmieri, Giuseppe Colombino, Maria Cossu, Antonio Marchetti, Antonio Botti, Gerardo Ascierto, Paolo A. J Transl Med Commentary The occurrence of high rates of somatic mutations in cancer is believed to correspond to increased frequency of neo-epitope formation and tumor immunogenicity. Thus, classification of patients with cancer according to degree a somatic hyper-mutational status could be proposed as a predictive biomarker of responsiveness to immunotherapy with immune checkpoint inhibitors. Here, we discuss the suitable and reliable tests easily adoptable in clinical practice to assess somatic mutational status in patients with advanced cancer. BioMed Central 2017-01-21 /pmc/articles/PMC5251272/ /pubmed/28109293 http://dx.doi.org/10.1186/s12967-017-1119-6 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Palmieri, Giuseppe
Colombino, Maria
Cossu, Antonio
Marchetti, Antonio
Botti, Gerardo
Ascierto, Paolo A.
Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?
title Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?
title_full Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?
title_fullStr Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?
title_full_unstemmed Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?
title_short Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?
title_sort genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251272/
https://www.ncbi.nlm.nih.gov/pubmed/28109293
http://dx.doi.org/10.1186/s12967-017-1119-6
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