Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1

BACKGROUND: Amyloid precursor protein (APP) is cleaved by β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) to produce β-amyloid (Aβ), a critical pathogenic peptide in Alzheimer’s disease (AD). Aβ generation can be affected by the intracellular trafficking of APP or its related secretases,...

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Detalles Bibliográficos
Autores principales: Kim, Na-Young, Cho, Mi-Hyang, Won, Se-Hoon, Kang, Hoe-Jin, Yoon, Seung-Yong, Kim, Dong-Hou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251330/
https://www.ncbi.nlm.nih.gov/pubmed/28109317
http://dx.doi.org/10.1186/s13195-016-0232-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251330/
https://www.ncbi.nlm.nih.gov/pubmed/28109317
http://dx.doi.org/10.1186/s13195-016-0232-8

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