Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling

The unfolding of apoptosis involves the cleavage of hundreds of proteins by the caspase family of cysteinyl peptidases. Among those substrates are proteins involved in intracellular vesicle trafficking with a net outcome of shutting down the crucial processes governing protein transport to organelle...

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Detalles Bibliográficos
Autores principales: Duclos, Catherine M, Champagne, Audrey, Carrier, Julie C, Saucier, Caroline, Lavoie, Christine L, Denault, Jean-Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253419/
https://www.ncbi.nlm.nih.gov/pubmed/28179995
http://dx.doi.org/10.1038/cddiscovery.2016.100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253419/
https://www.ncbi.nlm.nih.gov/pubmed/28179995
http://dx.doi.org/10.1038/cddiscovery.2016.100

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