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PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells

Increased glucose metabolism is considered as one of the most important metabolic alterations adapted by cancer cells in order to generate energy as well as high levels of glycolytic intermediates to support rapid proliferation. PH domain leucine-rich repeat protein phosphatase (PHLPP) belongs to a...

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Detalles Bibliográficos
Autores principales: Xiong, Xiaopeng, Wen, Yang-An, Mitov, Mihail I, C Oaks, Mary, Miyamoto, Shigeki, Gao, Tianyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253420/
https://www.ncbi.nlm.nih.gov/pubmed/28179998
http://dx.doi.org/10.1038/cddiscovery.2016.103