Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product

Farnesyl pyrophosphate synthase (FPPS) is an enzyme of the mevalonate pathway and a well-established therapeutic target. Recent research has focused around a newly identified druggable pocket near the enzyme's active site. Pharmacological exploitation of this pocket is deemed promising; however...

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Detalles Bibliográficos
Autores principales: Park, Jaeok, Zielinski, Michal, Magder, Alexandr, Tsantrizos, Youla S., Berghuis, Albert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253651/
https://www.ncbi.nlm.nih.gov/pubmed/28098152
http://dx.doi.org/10.1038/ncomms14132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253651/
https://www.ncbi.nlm.nih.gov/pubmed/28098152
http://dx.doi.org/10.1038/ncomms14132

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